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Simulated Digestion of Dried Leaves of Artemisia Annua Consumed as a Treatment (pACT) for Malaria

Artemisinin (AN) is produced by Artemisia annua, a medicinal herb long used as a tea infusion in traditional Chinese medicine to treat fever; it is also the key ingredient in current artemisinin-based combination therapies (ACTs) effective in treating malaria.

Published onJan 26, 2020
Simulated Digestion of Dried Leaves of Artemisia Annua Consumed as a Treatment (pACT) for Malaria
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Abstract

Artemisinin (AN) is produced by Artemisia annua, a medicinal herb long used as a tea infusion in traditional Chinese medicine to treat fever; it is also the key ingredient in current artemisinin-based combination therapies (ACTs) effective in treating malaria. Recently we showed that dried leaves from the whole plant Artemisia annua that produces artemisinin and contains artemisinin-synergistic flavonoids seem to be more effective and less costly than ACT oral malaria therapy; however little is known about how digestion affects release of artemisinin and flavonoids from dried leaves.

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Weathers, P. J., Jordan, N. J., Lasin, P., & Towler, M. J. (2014). Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria. Journal of Ethnopharmacology151(2), 858–863. https://doi.org/10.1016/j.jep.2013.11.043

*denotes a WPI undergraduate student author

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