by Meagan E. Carnes, Jeannine M. Coburn, Cailin R. Gonyea*, Rebecca G. Mooney, Jane W. Njihia, and George D. Pins
The goal of this work was to facilitate the logical design of enzymatically crosslinked fibrin microthreads with tunable structural properties, enabling their application for engineered tissue constructs with varied mechanical and structural properties.
by Edward Clancy, Michael Delph II*, Gregory Fischer, Sarah Fischer*, Phillip Gauthier*, and Carlos Martinez Luna*
This project developed a working prototype of the rehabilitative robotic glove which actuates the fingers over a full range of motion across one degree-of-freedom, and is capable of generating a maximum 15N grip force.
by Sinan Assad*, Ki Chon, Edward Clancy, Fangjie Ding*, Ningxin Fu*, Xinming Huang, Susan Jarvis, Quanquan Ma*, and 5 more
In this paper, a low power wireless PPG sensor has been designed. N-back M-pitch, a working memory cognitive test has been used to correlate HRV, extracted from the new sensor, with mental fatigue, indicated by lower accuracy in the test.
by K. L. Billiar, A. G. Christakis*, T. A. Gwyther, J. Z. Hu, M. W. Rolle, S. M. Shaw, and J.K. Skorinko
The goal of this study was to develop a system to rapidly generate engineered tissue constructs from aggregated cells and cell-derived extracellular matrix (ECM) to enable evaluation of cell-derived tissue structure and function.
by Kristen L. Billiar, Andrew K. Capulli*, Laura E. Firstenberg, Leslie N. Sierad*, and Angela M. Throm Quinlan
Cells have the ability to actively sense their mechanical environment and respond to both substrate stiffness and stretch by altering their adhesion, proliferation, locomotion, morphology, and synthetic profile.
by Kristen L. Billiar, Tracy A. Gwyther, Jason Z. Hu*, and Marsha W. Rolle
This article outlines a versatile method to create cell-derived tissue rings by cellular self-assembly. Smooth muscle cells seeded into ring-shaped agarose wells aggregate and contract to form robust three-dimensional (3D) tissues within 7 days.
by K. Billiar, G. Broderick, A. Christakas*, R. M. Dunn, Z. M. Hurwitz, R. A. Ignotz, J. F. Lalikos, J. McIntyre, and 3 more
The purpose of this study was to compare inflammatory responses, tissue integration, and strength of the acellular dermal collagen matrices AlloDerm®* Regenerative Tissue Matrix, Permacol™**Surgical Implant (Permacol), and CollaMend™*** Implant in a rat model.
by Olufunmilayo Adebayo*, Kristen L. Billiar, Tracy A. Hookway, Jason Z. Hu, and Marsha W. Rolle
In this study, we created self‐assembled smooth muscle cell (SMC) tissue rings (comprised entirely of cells and cell‐derived matrix; CDM) and compared their structure and material properties with tissue rings created from SMC‐seeded fibrin or collagen gels.
by Sakthikumar Ambady, Tanja Dominko, William F. Holmes, Victoria Huntress, Olga Kashpur, Denis Kole, Raymond L. Page, Lucy Vilner, and 2 more
Reprogramming of differentiated somatic cells into induced pluripotent stem (iPS) cells has potential for derivation of patient-specific cells for therapy as well as for development of models with which to study disease progression.
by Tanja Dominko, Emmett Hedblom, Jason Hu, Christopher Malcuit, Raymond L. Page, George D. Pins, Marsha W. Rolle, Sharon Shaw, and 2 more
Large-scale musculoskeletal wounds, such as those seen in trauma injuries, present poor functional healing prognoses. In severe trauma, when the native tissue architecture is destroyed or lost, the regenerative capacity of skeletal muscle is diminished by scar formation.
by Kristen Billiar, Heather Cirka, Vivian Liang*, Frederick J. Schoen, and Johana Uribe
In this study, we introduce and verify a highly reproducible in vitro method for studying dystrophic calcification of cardiac valvular interstitial cells, considered to be a key mechanism of clinical CAVD.